Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes mellitus.

s are drawn spanning the circle. Conservatively, we treated all monogenic loci (region 142) as a single locus by which connectivity was assessed. The strongest connections (P < 0.001) are colored in bright red. (d) GSEA of associations in the adipocytokine signaling pathway. Black bars represent the stage 1 meta-analysis P values of 63 autosomal genes in the adipocytokine signaling pathways (KEGG). Top, density plot of the black bars (red line). The replicating genes in the leading edge of the GSEA are listed. Stage 2 modified GSEA P = 1.6 × 10−4 was calculated on the basis of both the primary and secondary transcripts using the LD locus definition. a CREBBP subnetwork Adipocytokine subnetwork